Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome.
Published in medRxiv, 2023
Recommended citation: Gabbutt, C., Duran-Ferrer, M., Grant, H et al. (2023). "Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome." medRxiv. https://doi.org/10.1101/2023.11.10.23298336
In this study, we developed a novel computational method to infer the evolutionary dynamics of almost 2,000 blood cancers using methylation based lineage markers. We found the inferred evolutionary histories strongly predicted outcome in chronic lymphocytic leukaemia.