Calum Gabbutt

Calum Gabbutt

Mathematical Biology and Cancer Evolution

Publications

Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome.

Published in medRxiv, 2023

This study presents fluctuating methylation clocks (FMCs) as a novel lineage tracing marker and demonstrates how they can be employed to quantitively infer the clonal dynamics of healthy tissue.

Recommended citation: Gabbutt, C., Duran-Ferrer, M., Grant, H et al. (2023). "Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome." medRxiv. https://doi.org/10.1101/2023.11.10.23298336

Lineage tracing in human tissues

Published in Journal of Pathology, 2022

A review article outlining the various approaches to learning about dynamic biological processes from naturally occurring lineage markers. This included a discussion of historical approaches, such as the use of germline mutations, to gold standard modern approaches like multi-region whole genome sequencing.

Recommended citation: Gabbutt, C., Wright, N.A., Baker, A.-M., Shibata, D. and Graham, T.A. (2022). "Lineage tracing in human tissues." J. Pathol.. 257: 501-51. https://doi.org/10.1002/path.5911

Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues

Published in Nature Biotechnology, 2022

This study presents fluctuating methylation clocks (FMCs) as a novel lineage tracing marker and demonstrates how they can be employed to quantitively infer the clonal dynamics of healthy tissue.

Recommended citation: Gabbutt, C., Schenck, R.O., Weisenberger, D.J. et al. (2022). "Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues." Nat Biotechnol. 40, 720-730. https://doi.org/10.1038/s41587-021-01109-w

Evolution’s cartographer: Mapping the fitness landscape in cancer

Published in Cancer Cell, 2021

A spotlight highlighting Salehi et al. (2021) and discussing the potential impact that probing the cancer fitness landscape and how it changes in response to drug could have on predicting tumour evolution through therapy.

Recommended citation: Gabbutt, C, and Graham, T. A. (2021). "Evolution's Cartographer: Mapping the Fitness Landscape in Cancer." Cancer Cell. 39 (10): 1311-13. https://doi.org/10.1016/J.CCELL.2021.09.002.

AFM nanoindentation reveals decrease of elastic modulus of lipid bilayers near freezing point of water.

Published in Scientific Reports, 2019

A study applying atomic force microscopy to lipid membrane across a range of temperatures, probing the effect of freezing on the mechanical properties of lipid membranes. Research undertaken during MPhys project.

Recommended citation: Gabbutt, C., Shen, W., Seifert, J. et al. (2019). "AFM nanoindentation reveals decrease of elastic modulus of lipid bilayers near freezing point of water." Sci Rep. 9, 19473. https://doi.org/10.1038/s41598-019-55519-7

Crypt fusion as a homeostatic mechanism in the human colon

Published in Gut, 2019

In this study, evidence is presented for the existence of crypt fusion in the human colon, a novel homeostatic mechanism whereby two neighbouring intestinal crypts can merge to form a single daughter crypt. Joint first author.

Recommended citation: Baker A, Gabbutt C, Williams MJ, et al (2019). "Crypt fusion as a homeostatic mechanism in the human colon " Gut . 2019;68:1986-1993. http://dx.doi.org/10.1136/gutjnl-2018-317540