Crypt fusion as a homeostatic mechanism in the human colon
Baker A, Gabbutt C, Williams MJ, et al (2019). "Crypt fusion as a homeostatic mechanism in the human colon " Gut . 2019;68:1986-1993.
CV
Employment
- 2024 - Present: Chapman-Schmidt AI in Science Postdoctoral Fellow
- Imperial College London
- 2022 - 2024: Postdoctoral Training Fellow
- Institute of Cancer Research
- 2022: Postdoctoral Research Assistant
- Barts Cancer Institute, Queen Mary University of London
- 2021: Research Intern
- CC Bio
Education
- Ph.D “Quantitative measurement of clonal evolution in human colon”, Barts Cancer Institute, Queen Mary University of London, 2017-2022
- Supervisor: Professor Trevor Graham and Professor Chris Barnes
- MPhys in Physics (First Class Honours), University of Oxford, 2013-2017
- Awarded the NTT Prize for an MPhys Project in Biological Physics
Skills
- High mathematical proficiency and considerable experience applying mathematical methods to biological systems, particularly with regard to somatic evolution and population genetics.
- Excellent knowledge of a variety of coding languages (Python, Matlab, R, Stan), with extensive experience analysing large datasets, simulating physical systems and performing Bayesian inference.
- Experience working with a high-performance computing cluster.
- Highly experienced working collaboratively with both internal and external collaborators.
- Confident public speaker, comfortable presenting complex information to a wide range of technical and/or lay audiences.
Publications
AFM nanoindentation reveals decrease of elastic modulus of lipid bilayers near freezing point of water.
Gabbutt, C., Shen, W., Seifert, J. et al. (2019). "AFM nanoindentation reveals decrease of elastic modulus of lipid bilayers near freezing point of water." Sci Rep. 9, 19473.
Evolution’s cartographer: Mapping the fitness landscape in cancer
Gabbutt, C, and Graham, T. A. (2021). "Evolution's Cartographer: Mapping the Fitness Landscape in Cancer." Cancer Cell. 39 (10): 1311-13.
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
Gabbutt, C., Schenck, R.O., Weisenberger, D.J. et al. (2022). "Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues." Nat Biotechnol. 40, 720-730.
Lineage tracing in human tissues
Gabbutt, C., Wright, N.A., Baker, A.-M., Shibata, D. and Graham, T.A. (2022). "Lineage tracing in human tissues." J. Pathol.. 257: 501-51.
Phenotypic plasticity and genetic control in colorectal cancer evolution.
Househam, J., Heide, T., Cresswell, G.D. et al. (2022). "Phenotypic plasticity and genetic control in colorectal cancer evolution." Nature. 611, 744-753.
Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome.
Gabbutt, C., Duran-Ferrer, M., Grant, H et al. (2023). "Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome." medRxiv.
Talks
Integrated Mathematical Oncology - Evolutionary Therapy
Workshop at Moffitt Cancer Center, Tampa FL, USA
‘The tick-tock clock’ - Exploiting the distribution of methylation patterns within single colonic crypts to infer intra-crypt dynamics.
Poster at Junior Investigator Meeting, Physical Sciences - Oncology Network, Washington DC, USA
Cell Imaging Hackathon
Workshop at CSBC/PS-ON Image Analysis Working Group, Vanderbilt University, Nashville TN, USA
Reconstructing Contemporary Human Stem Cell Dynamics with Oscillatory Molecular Clocks
Talk at Society of Mathematical Biology,
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
Talk at Cancer Systems Biology Consortium West Coast Symposium 2022, San Diego CA, USA
Dynamics and Statistics of Cancer Evolution
Summer School at Centre International de Rencontres Mathematiques, Marseille, Marseille, France
Lineage tracing methods to measure evolutionary dynamics in cancer
Minisymposium at Mathematical Models in Ecology and Evolution Conference, University of Reading, Reading, UK
Fluctuating methylations clocks allow for the quantification of the evolutionary dynamics in blood cancers
Talk at Physics of Life 2023, Institute of Physics, Harrogate, UK
Fluctuating methylation clocks are a flexible tool for measuring ongoing somatic evolution in healthy tissue and cancer
Invited Guest Speaker at Crick Evolution Forum, Francis Crick Institute, London, UK
Methylation-based lineage markers as a novel method to measure a cancer’s evolutionary dynamics.
Invited Guest Speaker at CRUK Convergence Science Centre, Imperial & ICR, London, UK
Timing copy number alterations in Barrett’s oesophagus in absolute time.
Oral Plenary Speaker at Pathology and Precision Medicine, Royal Society of Medicine, London, UK
Fluctuating methylation as a high temporal-resolution molecular clock to track lineages in vivo.
Invited Speaker at Cell Lineages Across Scales, Space and Time, Royal Society, Birmingham, UK
Quantification of the evolutionary history of a cancer from bulk methylation data using stochastic modelling and Bayesian inference.
Contributed Talk at Joint Annual Meeting of the Korean Society for Mathematical Biology and the Society for Mathematical Biology 2024, Seoul, South Korea
Learning a cancer’s evolutionary history from bulk methylation data using Bayesian inference.
Contributed Talk at European Conference on Mathematical and Theoretical Biology 2024, Toledo, Spain
Leveraging inference of cancer evolution to improve patient stratification.
Invited Seminar at Early Cancer Institute, Cambridge, UK